Download PDF Understanding Histamine Intolerance & Mast Cell Activation, by Mariska Wild-Scholten
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Understanding Histamine Intolerance & Mast Cell Activation, by Mariska Wild-Scholten
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Histamine intolerance and Mast Cell Activation result in allergy-like symptoms. Histamine-rich food or mast cell degranulators may cause diarrhea or constipation, low or high blood pressure, eczema, asthma, acid reflux, migraine, depression, rapid heart beats and breathing, panic attacks and sleep disturbances. This book describes the symptoms, assists in diagnosis and treatment. Basic knowledge is given to help patients to understand their enemy. Lists are included with concentrations of biogenic amines, mast cell degranulators and medicines which must be avoided. References and abstracts to scientific literature are provided as well.
- Sales Rank: #534891 in eBooks
- Published on: 2015-06-03
- Released on: 2015-06-03
- Format: Kindle eBook
Most helpful customer reviews
64 of 64 people found the following review helpful.
OK but glaring inexcusable errors concerning Methylation's role in Histamine Intolerance.
By Linda E. N-Eaton
This is an Ok book and has a lot of good useful information all in one place. As someone with histamine intolerance with gene defects that code for DAO, MAO, and HNMT finding out that turmeric blocked MAO was very useful as well as finding out exactly how Vitamin C works as an antihistamine. Her charts, while somewhat confusing are also useful. With such information in mind, as an herbalist and nutritionist, I was able to search for other herbs and supplements that also block either DAO or MAO and or other critical enzymes.
However this book also has some very glaring misinformation and leaves out some extremely important information. The most glaring error of all, and there should be no excuse anymore for anyone writing on histamine intolerance to make such an error, is that the author falsely claims that Methylation is "quackery" when it comes to histamine intolerance just because she read such on Wikipedia, and also after correctly noting that ""The HNMT [Histamine N-methytransferase] enzyme catalyzes the reaction of histamine with a methyldonor to N-methylhistamine."
If Ms. de Wild-Scholten had actually researched the full methylation and histamine pathways she would have realized that Wikipedia was totally wrong about methylation's role in histamine degradation. The HNMT enzyme is a methyltransferase enzyme which means it takes SAMe as a cofactor to work and SAMe is generated by the MAT enzyme converting the amino acid Methionine into SAMe using the cofactor Magnesium and ATP. If someone is going to write a book on histamine intolerance and then go so far as to slander Carl Pfeiffer and his ground breaking work as "Histadalia/Methylation Quackery", they had better do their homework first. If Mr. Pfeiffer was alive he could have sued Ms. de Wild-Schollen for her slander.
If someone has methylation issues such as an MTHFR defect, an MAT defect, a CBS upregulation defect etc. SAMe cannot be generated or recycled properly, or is turned into homocysteine too quickly (by the CBS upregulated enzyme) and histadalia can indeed be the result. I am homozygeous (two bad copies, one from each parent) on the gene that codes for the MAT enzyme, and have many other defects in the methyl cycle as well (including the genes that code for both critical MTHFR enzymes). In addition I am homozygeous for defective genes that code for both the critical DAO enzymes and the MAO A enzyme, and heterozygous for all my HNMT enzymes except one. The minute I took 500 mg of methionine I woke up for the first time in my life with out the blinding histamine headache I had endured every morning of my life and for half of the day every day.
Granted we know much more about how the methyl cycle works now, but such a glaring error by Ms. de Wild-Scholten in this day and age is nothing short of inexcusable.
So if you choose to purchase this book, please disregard the authors misinformation concerning Methylation.
8 of 8 people found the following review helpful.
Very detailed and well-explained
By NK
I found this book to be very useful. As a high-frequency migraine sufferer, I have suspected histamine intolerance to be a primary trigger for some time. The author explains the difference between DAO and HNMT enzymes and gives valuable case-history info. A must-read for anyone with frequent migraines.
10 of 11 people found the following review helpful.
A very useful book
By Jan Treur
I bought this book a few months ago. It turns out to be very useful. The author has spent much effort in bringing together what is known from large amount of sources, and to integrate it in a general perspective. At many points the different causal pathways are described in a level of detail that is hard to find in other sources. For those interested in the complex mechanisms behind histamine intolerance who are not able or do not want to do all this work by themselves, this book is a very helpful source.
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